How Saxenda Works: Understanding the Science Behind the Injection

Introduction

If you’re considering Saxenda in Dubai, you’ve likely asked yourself: How does Saxenda actually work? Understanding the science behind this revolutionary medication can help you use it more effectively and with greater confidence.

Saxenda (liraglutide) is more than just an appetite suppressant. It’s a medically approved injectable that works through hormonal regulation, targeting the body’s natural mechanisms for hunger and satiety.

In this blog, we’ll explore how Saxenda works, its connection to GLP-1 hormones, and why it’s considered one of the safest non-surgical options for weight loss in Dubai.

What is Saxenda?

Saxenda is a prescription-only injectable weight loss medication that mimics the effects of a natural hormone called GLP-1 (glucagon-like peptide-1).

It was originally developed as a diabetes drug (under the name Victoza) and later approved for chronic weight management due to its unique ability to control appetite and reduce calorie intake.

Saxenda is approved by:

• FDA (USA)

• EMA (Europe)

• MOHAP and DHA in the UAE

The Science Behind Saxenda: GLP-1 Hormone Explained

What is GLP-1?

GLP-1 is a naturally occurring gut hormone that is released after eating. It plays a critical role in:

• Slowing gastric emptying

• Stimulating insulin secretion

• Reducing glucagon secretion

• Sending fullness signals to the brain

How Saxenda Imitates GLP-1

Saxenda is a GLP-1 receptor agonist, meaning it mimics the GLP-1 hormone and activates its receptors in the brain and gut.

This leads to:

• Increased satiety (feeling full)

• Reduced appetite

• Delayed stomach emptying

• Fewer cravings and less food intake

How Saxenda Affects the Brain

Saxenda crosses the blood-brain barrier and binds to GLP-1 receptors in the hypothalamus, a part of the brain responsible for regulating hunger.

Result:

• Reduced hunger signals

• Increased sense of fullness after small meals

• Less emotional and impulse eating

 Saxenda works not just on your stomach, but also rewires your brain’s response to food.

How Saxenda Affects the Digestive System

Saxenda slows down gastric emptying, which means food stays in your stomach longer. This prolongs the feeling of fullness and helps control:

• Portion sizes

• Snacking frequency

• Overall calorie intake

Slower digestion also improves blood sugar stability, which reduces sugar cravings—a major benefit for patients with prediabetes or insulin resistance.

Weekly Dose Titration of Saxenda

To minimize side effects, Saxenda is started at a low dose and gradually increased.

WeekDaily Dose (mg)PurposeWeek 10.6 mgInitial doseWeek 21.2 mgBody adaptationWeek 31.8 mgEnhanced appetite controlWeek 42.4 mgNear maintenanceWeek 5+3.0 mgFull therapeutic dose

Benefits of Saxenda’s Mechanism of Action

 Reduces Appetite Naturally
Unlike stimulants, Saxenda doesn’t force weight loss—it works in harmony with your body’s hormones.

 No Impact on Metabolism or Heart Rate (Unlike Fat Burners)
It doesn’t overstimulate your body or cause jittery feelings.

 Clinically Proven for Sustainable Weight Loss
Most users in clinical trials lost 5% to 10% of their body weight in 12–24 weeks.

 Supports Behavioral Change
By reducing cravings and emotional eating triggers, it helps develop long-term healthy habits.

Saxenda vs Other Weight Loss Methods

MethodHow It WorksNatural Hunger ControlSustainabilityRequires Surgery?Saxenda InjectionGLP-1 Hormone Regulation Yes High NoFat BurnersStimulants Increase Metabolism No Low NoGastric BalloonPhysically reduces stomach capacity Partial Moderate YesLiposuctionRemoves fat tissue manually No Low Yes

Scientific Studies Supporting Saxenda

Several international clinical trials have shown Saxenda’s efficacy:

• Study: SCALE Obesity and Prediabetes
  Results: Patients lost an average of 8.4 kg over 56 weeks

• Study: LEAD Trials
  Result: Improved blood sugar levels, reduced food cravings, and improved metabolic profiles

• UAE-Based Study (DHA registered)
  Result: Over 70% of patients reported sustained appetite reduction and improved lifestyle behavior after 6 months

Is Saxenda Right for You?

You may be a candidate for Saxenda if:

• Your BMI is 30 or higher

• Your BMI is 27 or higher with weight-related health issues (e.g., high blood pressure, type 2 diabetes)

• You’ve struggled to lose weight through diet and exercise alone

Always consult a DHA-certified weight loss doctor in Dubai to assess your eligibility and create a personalized plan.

Final Thoughts: Saxenda is Smart Science for Sustainable Weight Loss

The power of Saxenda lies in its scientific approach—it doesn’t crash your system or suppress appetite artificially. It works with your body’s natural hormones, making it a safe, sustainable solution for long-term weight management.

Whether you’re starting Saxenda in Dubai or just exploring your options, understanding how Saxenda works gives you the knowledge to make informed, confident decisions.